In 1992, Dr. Juan Tapia-Mendoza founded the Pediatrics 2000 group. He was soon joined by a new generation of medical providers dedicated to working in underserved urban communities. In January of 1993, Pediatrics 2000 opened its doors at 150th Street and Broadway in West Harlem, NY: a federally designated health shortage community plagued with a high prevalence of asthma, teen pregnancy, obesity, and behavioral problems. Pediatrics 2000 introduced the concept of a private Pediatric group practice to the neighborhood and was the first open access clinic for a Medicaid eligible population in the area. It was the first clinic of its kind to treat acute asthma attacks with medicines administered via nebulizer instead of the traditional asthma injections known for its side effects and limitations.

Over the years, Pediatrics 2000 has partnered with major community institutions, including the National Health Service Corps, to support and continue to advance primary care in underserved areas, promote educational programs to improve health literacy and foster medical research and pro bono work.

Pediatrics 2000 has been featured in the New York Times, NBC, CBS, Telemundo, Univision, national networks as well as ABC channel-7, The Fox channel 5 local news, El Diario la Prensa, The Amsterdam News and 'New Yorker Of The Week' by NY-1 News, among other media coverage. Pediatrics 2000 currently has 2 sites and over 20,000 patient visits per year.

In 2008 the Pediatrics 2000 group was the first in its area to incorporate Electronic Medical Records into its practice and among the pioneers in valuing the concept of the Patient Centered Medical Home in a Pediatric practice.